PGD is employed in couples who are at a very high risk of having a child with a severe genetic disorder or at a high risk of losing the baby due to a chromosome abnormality. PGD has been utilised before to screen for other disorders.
Maastricht UMC+’s Clinical Genetics unit will assess the hereditary aspects of each case. After that, all indications for PGD will be discussed in MUMC+’s PGD working group. If PGD is requested to screen for a disorder for which PGD has not been utilised before, the request must be submitted to the National PGD Indications Committee. Needless to say, it must be technologically possible to screen embryos for the disorder in question.
Couples who wish to undergo IVF/PGD must satisfy the requirements for IVF. If the woman is aged 41 or older, the couple is no longer eligible for PGD in the Netherlands. If the woman is aged 40 (but has not yet turned 41), an individual assessment of her eligibility for IVF/PGD will be performed. If the woman is overweight (maximum BMI: 35), she will not be eligible for PGD. Gynaecologists or doctors working on the IVF team will determine whether couples are good IVF candidates, e.g. by subjecting the woman to hormone evaluation and the man to semen analysis.