The procedure

IVF / ICSI

IVF involves in-vitro fertilisation by uniting egg cells and sperm cells in a laboratory. If the man suffers from defective sperm function, ICSI (intracytoplasmic sperm injection) may be utilised to inject a sperm cell into an egg cell. If PGD is utilised for DNA diagnostic purposes, ICSI will be employed as well.

The initial consultation

Prior to the first PGD treatment, the couple will be invited for a consultation during which a nurse will discuss the procedure and provide instructions on how to administer the hormone injections. The couple will receive a print-out of the drug administration schedule and follow-up appointments will be scheduled. In addition, the IVF doctor will carry out an internal ultrasound scan of the ovaries.

The IVF procedure

Several weeks before the start of the procedure, the woman will start taking birth control pills. After that the patient will commence self-administering Decapeptyl injections. Once she has taken Decapeptyl for 12 to 14 days, she will start administering Puregon injections to stimulate follicles. Several ultrasound scans will be performed to assess the ripening of the follicles. Once a sufficient number of follicles has grown, follicular punction will be conducted. Three days later, the embryos will undergo biopsy. Four days after follicular puncture the embryos will be implanted in the uterus. Two weeks after the implantation, a pregnancy test may be taken.

Before and during the IVF/PGD treatment we recommend to avoid a spontaneous pregnancy and use safe contraceptive methods. Also after the IVF/PGD treatment contraception methods should be continued. Your gynaecologist will discuss this issue with you.

More information on the IVF procedure can be found on the websites of the IVF centres participating in PGD Netherlands:
IVF-centrum MUMC+
IVF-centrum UMCU
IVF-centrum UMCG
IVF-centrum AMC